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HIV p17 Gag (77-85)

PURITY:≥98%

CAT.NO:ONP10894

CAS.NO:147468-65-3

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1mg Check Stock 99
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BIOLOGICAL INFORMATION
Description HIV-1 gag p17 protein is an attractive target for molecular intervention, because it is involved in the viral replication cycle at both the pre- and postintegration levels. In the present experiments, we targeted p17 by intracellularly expressing a cDNA encoding an Ab to p17. cDNA from a hybridoma-secreting Ab to p17 was cloned, sequenced, reconstructed as a single-chain Ab fragment (scFv), and expressed in the cytoplasm or nucleus with appropriate retention signals. The expressed scFvs had no effect on T cell growth or CD4 expression and bound specifically to HIV-1 p17. Human CD4+ Jurkat T cells that expressed scFvs and were infected with HIV-1 showed a marked reduction in virus replication compared with cells expressing vector alone. The inhibition of virus replication was more pronounced when scFvs were expressed in the cytoplasm rather than the nucleus. From these studies, we conclude that the intracellular expression of a single-chain Ab to p17 inhibits HIV replication; in addition, the degree of inhibition is related to the intracellular targeting site.
Application Melanocortin
Note For research only, not for human use!
CHEMICAL INFORMATION
CAT No. ONP10894
CAS No. 147468-65-3
Name HIV p17 Gag (77-85)
Chemical Name HIV-p17-Gag-(77-85)
Purity ≥98%
Synonyms N/A
Formula C44H72N10O15
Molecular Weight 981.11
One Letter Code SLYNTVATL
Three Letter Code SER-LEU-TYR-ASN-THR-VAL-ALA-THR-LEU
SMILES CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NC(C(C)C)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CO)N
InChI Key HQPMZGASBMYMTQ-CPRZOGMTSA-N
Source Synthetic
Form Dry Powder
Color White
Solubility N/A
SHIPPING & STORAGE
Storage 4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
Shipping Ice Pack
Stability ≥ 2 years
PROMOTIONS & EVENTS
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